About Dietary Supplement Science & Evidence
Nutritional science continuously evaluates botanical extracts, adaptogens, amino acids, vitamins, and minerals for their physiological mechanisms and contributions to human metabolic health. The citations compiled on this page represent independent, third-party scientific studies published in recognized peer-reviewed medical journals and resources maintained by major government and scientific bodies.
Please note: The studies cited below evaluate individual raw ingredients or isolated nutrients and do not constitute an evaluation, endorsement, or approval of any proprietary finished supplement product.
Active Ingredients & Peer-Reviewed Scientific Studies
Tongkat Ali (Eurycoma longifolia)
Traditionally utilized in Southeast Asia, Tongkat Ali contains bioactive quassinoids, eurycomanone, and glycosaponins studied for their relationship with cortisol regulation, physical endurance, and male vitality.
Key Published Citations:
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Journal of the International Society of Sports Nutrition:
Talbott SM, et al. "Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects." (2013).
PMID: 23705671 » -
Phytotherapy Research:
Henkel RR, et al. "Tongkat Ali as a potential herbal supplement for physically active male and female seniors." (2014).
PMID: 24559202 »
Panax Ginseng (Asian Ginseng)
Renowned for its concentration of ginsenosides, Panax Ginseng is widely researched for its role in cellular energy metabolism, fatigue reduction, cognitive performance, and general vitality.
Key Published Citations:
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PLOS ONE:
Kim HG, et al. "Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial." (2013).
PMID: 23613825 » -
Journal of Psychopharmacology:
Reay JL, et al. "Panax ginseng improves aspects of working memory performance and subjective ratings of calmness in healthy young adults." (2010).
PMID: 20667954 »
Maca Root (Lepidium meyenii)
Native to the high Andes of Peru, Maca is rich in macamides, glucosinolates, and vital minerals. Research focuses on its potential support for stamina, physical energy, and subjective vitality.
Key Published Citations:
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Journal of Ethnopharmacology:
Stone M, et al. "A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen." (2009).
PMID: 19781622 » -
Andrologia:
Gonzales GF, et al. "Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men." (2002).
PMID: 12472620 »
L-Arginine
An essential semi-essential amino acid that serves as the biological substrate for endothelial nitric oxide synthase (eNOS), which regulates vasodilation, blood flow dynamics, and vascular tissue oxygenation.
Key Published Citations:
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British Journal of Clinical Pharmacology:
Bode-Böger SM, et al. "L-arginine-induced vasodilation in healthy humans: relation to nitric oxide production." (1998).
PMID: 9860494 » -
Applied Physiology, Nutrition, and Metabolism:
Alvares TS, et al. "Acute L-arginine supplementation increases muscle blood volume and vascular conductance." (2012).
PMID: 22260513 »
Ashwagandha (Withania somnifera)
Concentrated with withanolides, Ashwagandha has been extensively researched for modulating hypothalamic-pituitary-adrenal (HPA) axis activity, healthy cortisol balance, and muscular recovery.
Key Published Citations:
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Indian Journal of Psychological Medicine:
Chandrasekhar K, et al. "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of high-concentration Ashwagandha root extract." (2012).
PMID: 23439798 » -
Journal of the International Society of Sports Nutrition:
Wankhede S, et al. "Examining the effect of Withania somnifera supplementation on muscle strength and recovery." (2015).
PMID: 26609282 »
Tribulus Terrestris
Known for its protodioscin content, Tribulus has been evaluated across sports physiology and male wellness literature for endurance support, athletic conditioning, and nitric oxide pathways.
Key Published Citations:
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Journal of Human Kinetics:
Pokrywka A, et al. "Insights into Supplements with Tribulus Terrestris used by Athletes." (2014).
PMID: 25161429 » -
Phytomedicine:
Gauthaman K, et al. "Aphrodisiac properties of Tribulus Terrestris extract in normal and castrated rats." (2002).
PMID: 12126073 »
Saw Palmetto (Serenoa repens)
Rich in fatty acids and phytosterols, Saw Palmetto has been widely evaluated in clinical urology literature regarding its interaction with 5-alpha reductase pathways and male lower urinary tract wellness.
Key Published Citations:
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Cochrane Database of Systematic Reviews:
Tacklind J, et al. "Serenoa repens for benign prostatic hyperplasia." (2012).
PMID: 23235581 » -
NIH National Center for Complementary and Integrative Health:
NCCIH Health Information: "Saw Palmetto: Fact Sheet for Health Professionals."
NIH NCCIH Portal »
Zinc & Magnesium
Zinc and Magnesium are critical trace cofactors for over 600 enzymatic reactions in the human body, directly supporting cellular repair, protein synthesis, DNA maintenance, and hormonal metabolism.
Key Published Citations:
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Molecular Medicine:
Prasad AS. "Zinc in human health: effect of zinc on immune cells and metabolic health." (2008).
PMID: 18385818 » -
NIH Office of Dietary Supplements (ODS):
"Zinc and Magnesium Fact Sheets for Health Professionals."
NIH ODS Database »
Vitamin D3 & Selenium
Vitamin D3 operates as a potent secosteroid hormone supporting endocrine balance and musculoskeletal integrity, while Selenium serves as an essential component of selenoproteins combating oxidative stress.
Key Published Citations:
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Hormone and Metabolic Research:
Pilz S, et al. "Effect of vitamin D supplementation on testosterone levels in men." (2011).
PMID: 21154383 » -
The Lancet:
Rayman MP. "Selenium and human health: a systematic evaluation of selenoproteins." (2012).
PMID: 22381456 »
Vitamin B-Complex (B6, B12, Niacin, Folate)
B vitamins serve as indispensable enzymatic coenzymes in cellular energy pathways, including the Krebs cycle and mitochondrial ATP synthesis, as well as neurovascular neurotransmitter synthesis.
Key Published Citations:
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Nutrients:
Kennedy DO. "B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review." (2016).
PMID: 26828517 » -
Harvard T.H. Chan School of Public Health:
The Nutrition Source: "B Vitamins and Human Metabolic Energy Systems."
Harvard Health Resource »
Authoritative Public Health & Scientific Research Portals
For verified dietary supplement facts, monograph databases, and peer-reviewed clinical research repositories, consumers and healthcare providers can consult these recognized national and international scientific organizations:
PubMed / NCBI
The world's leading database of biomedical and life sciences literature, maintained by the National Library of Medicine.
Visit pubmed.ncbi.nlm.nih.gov »NIH Office of Dietary Supplements
Authoritative resource from the U.S. National Institutes of Health providing evidence-based ingredient fact sheets.
Visit ods.od.nih.gov »NIH NCCIH
The National Center for Complementary and Integrative Health provides scientific evaluation of botanical therapies.
Visit nccih.nih.gov »MedlinePlus
Consumer-oriented medical information from the U.S. National Library of Medicine on dietary herbs and supplements.
Visit medlineplus.gov »Linus Pauling Institute
Oregon State University's Micronutrient Information Center offering comprehensive reviews of vitamins and minerals.
Visit lpi.oregonstate.edu »World Health Organization
Global public health monographs, nutritional safety benchmarks, and international dietary standards.
Visit who.int »Scientific Information & Regulatory Disclaimer
The scientific literature, published clinical trials, and public health database citations referenced on this page are provided strictly for educational and informational purposes. These citations discuss peer-reviewed research concerning individual raw ingredients, amino acids, vitamins, and minerals.
The presence of an academic study or scientific reference on this page does not imply that any governmental agency, university, medical center, or research author endorses JellyFill or that JellyFill will produce identical outcomes to individual study designs.
Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration (FDA). JellyFill is a dietary supplement designed to support general male wellness; it is not a prescription medication and is not intended to diagnose, treat, cure, or prevent any disease. Always speak with a qualified physician before starting any dietary supplement.